Type 2 diabetic patients and Hba1c as a potential biomarker for dyslipidemia occurrence

  • Salah Mohamed Bilgasem Faculty of Medical Technology University of Tripoli
Keywords: glycated hemoglobin (HbA1c), Type 2 diabetes mellitus (T2DM), Total cholesterol (TC), HDL-C, LDL-C, Triglycerides (TG), Cardiovascular disease (CVD).


Abnormalities of lipid metabolism are important risk factors for an increased incidence of diabetes-related complications including coronary heart disease, peripheral artery disease and stroke. One of the most important indicator of the risk of this complication is the increase of HbA1c and the abnormalities of lipid profile. The aim of this study was to trace back if there is an association of HbA1c increase and the increase of lipid profile in type 2 diabetic patients. The 50 sample from patients with type 2 diabetes and another 50 sample was taken as a control from non-diabetes (normal), blood was collected and serum HbA1c was measured by COBAS INTEGRA 400 PLUS. Total cholesterol, HDL-C, LDL-C and TG levels measured by using reagents kit of bio-labo in which an open system device based on enzymatic substrate reaction (BIOLABO-KENZAMAX Device) was used. Results shows there is a significant increase of HbA1c, total cholesterol, HDL-C and LDL-C in patients with type 2 diabetes in comparison with control. The difference between control and samples was statistically significant and the p-value for HbA1c (p = 0.00), cholesterol (p = 0.002), HDL-C (p = 0.003) and for LDL-C (p = 0.001). The negative associations between type 2 diabetes and Triglycerides were found in which p-value was 0.362. I conclude, the elevation level of HbA1c companied with elevation of total cholesterol, HDL-C and LDL-C in patients with type 2 diabetes. The measurement of HbA1c may take as a potential biomarker for predicting dyslipidemia in patients with type 2 diabetes.